rs RS 504393
- 公司名稱 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型號(hào) rs
- 產(chǎn)地
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2019/7/4 8:54:26
- 訪問次數(shù) 713
聯(lián)系我們時(shí)請(qǐng)說明是化工儀器網(wǎng)上看到的信息，謝謝!
MedChemExpress (MCE) 專注于為科學(xué)家提供高品質(zhì)的生物活性小分子化合物，化合物庫及各類試劑盒，總部位于美國新澤西。
• MedChemExpress (MCE) 產(chǎn)品作用于 20 多個(gè)熱門信號(hào)通路及研究領(lǐng)域的300多個(gè)細(xì)分靶點(diǎn)，擁有 10000 特異性抑制劑、激動(dòng)劑，以及 50 活性化合物篩選庫；
• 我們堅(jiān)持對(duì)所有產(chǎn)品進(jìn)行嚴(yán)格質(zhì)檢，確保產(chǎn)品的高品質(zhì)和高純度；
• MedChemExpress (MCE) 產(chǎn)品已被數(shù)萬名科學(xué)家信賴，并被大量top文獻(xiàn)和*引用；
• 我們擁有專業(yè)的技術(shù)團(tuán)隊(duì)追蹤前沿科研進(jìn)展，不斷豐富各個(gè)靶點(diǎn)的特異性產(chǎn)品，堅(jiān)持做 “您身邊的抑制劑大師”；
• MedChemExpress (MCE) 與眾多藥企和科研機(jī)構(gòu)保持深度合作；
• 大量產(chǎn)品有中國庫存，工作日 16:00 前訂單確保當(dāng)日發(fā)貨，次日送達(dá)。
MCE 中國站：www.MedChemExpress.cn
Hotline: 400-820-3792
Tel: 021-58955995
Email: sales@MedChemExpress.cn
Tech Support: 021-58950656
抑制劑，調(diào)節(jié)劑，API，天然產(chǎn)物，各種類型化合物庫
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL；5 mg；10 mg |
|---|---|---|---|
| 貨號(hào) | HY-15418 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
RS 504393
產(chǎn)品活性：RS 504393 是一種選擇性的 CCR2 拮抗劑，作用于人重組 CCR2 和 CCR1 受體，IC50 值分別為 89 nM 和 > 100 μM。
研究領(lǐng)域：GPCR/G Protein | Immunology/Inflammation
作用靶點(diǎn)：CCR
In Vitro: RS 504393 inhibits the MCP-1-induced chemotaxis with an IC50 of 330 nM. RS 504393 treatment suppresses allergen induced β-hexosaminidase release significantly. Without allergen priming, MCP-1 induces mast cell degranulation, which is completely suppressed by RS 504393.
In Vivo: RS504393 (0.3-3 μg) with CCL2 progressively blocks thermal hyperalgesia dose-dependently in mice. RS 504393 (5?mg/kg, i.v.) supresses the elevated numbers of leukocytes and increased total protein content in BALF induced by The LPS. RS504393 significantly down regulates the LPS-induced elevation of IL-1β, PAI-1 mRNA and protein expressions. RS504393 significantly suppresses induced lung edema, protein-rich fluid, polymorphonuclear accumulation and bronchial wall thickening induced by LPS. RS-504393 significantly reduces renal pathology, especially the extensive interstitial fibrosis mediated by decrease in type I collagen synthesis in a UUO model.
相關(guān)產(chǎn)品：GPCR/G Protein Compound Library | Small Molecule Immuno-Oncology Compound Library | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Maraviroc | Cenicriviroc | INCB3344 | BX471 | PF-4136309 | RS102895 hydrochloride | TAK-779 | Vercirnon | AZD2098 | MK-0812 Succinate | CCX140 | INCB 3284 | ZK756326 dihydrochloride | TAK-220 | BMS-813160 | CCR2-RA-[R] | DAPTA | Vicriviroc maleate | GSK2239633A | CCR6 inhibitor 1 | SB297006 | Teijin compound 1 | Aplaviroc | AZ084 | CCR1 antagonist 1
采購中心
化工儀器網(wǎng)