S80070
具體成交價(jià)以合同協(xié)議為準(zhǔn)
- 公司名稱(chēng) 上海源葉生物科技有限公司
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- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2025/5/15 20:21:57
- 訪問(wèn)次數(shù) 191
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- 產(chǎn)品描述： Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells.
- 靶點(diǎn)： 5-HT2A Receptor;5-HT2C Receptor
- 體內(nèi)研究： Sertindole (oral gavage; 10?mg/kg; once daily; 12 d) shows anti-tumor activity in vivo
- 參考文獻(xiàn)：
1. David Murdoch, et al. Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55. 2. Wei Zhang, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018 Oct 25;8(1):15753. 3. Mario F Juruena, et al. Sertindole in the management of schizophrenia. J Cent Nerv Syst Dis. 2011 May 17;3:75-85.
- 溶解度： DMSO : 25 mg/mL (56.70 mM; Need ultrasonic)
- 保存條件： -20℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.268 ml 11.339 ml 22.679 ml 5 mM 0.454 ml 2.268 ml 4.536 ml 10 mM 0.227 ml 1.134 ml 2.268 ml 50 mM 0.045 ml 0.227 ml 0.454 ml
- 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的性，僅供客戶(hù)參考交流研究之用。
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