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Nature：一組新的糖運(yùn)輸?shù)鞍?/h3>
閱讀：777 發(fā)布時間：2010-12-18
一組以前不知道的糖運(yùn)輸?shù)鞍滓驯蛔R別出來——zui初是在植物中， 但由于同源蛋白明顯廣泛分布，所以它們也在動物中被識別出。
在植物中，這些SWEET受體相應(yīng)于那些人們長期尋找的、向花蜜、種子和花粉發(fā)育供應(yīng)葡萄糖的運(yùn)輸?shù)鞍?。這些運(yùn)輸?shù)鞍字械钠渲幸恍┍徊≡w利用來為復(fù)制提供糖。后生動物同源蛋白也調(diào)控葡萄糖運(yùn)輸，并且還可能涉及糖從小腸、肝臟、附睪和乳腺細(xì)胞中的流出。（生物谷）
英文摘要：
Nature doi:10.1038/nature09606
Sugar transporters for intercellular exchange and nutrition of pathogens
Li-Qing Chen, Bi-Huei Hou, Sylvie Lalonde, Hitomi Takanaga, Mara L. Hartung, Xiao-Qing Qu, Woei-Jiun Guo, Jung-Gun Kim, William Underwood, Bhavna Chaudhuri, Diane Chermak, Ginny Antony, Frank F. White, Shauna C. Somerville, Mary Beth Mudgett & Wolf B. Frommerwfrommer@carnegiescience.edu
Sugar efflux transporters are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. Despite broad biological importance, the identity of sugar efflux transporters has remained elusive. Using optical glucose sensors, we identified a new class of sugar transporters, named SWEETs, and show that at least six out of seventeen Arabidopsis, two out of over twenty rice and two out of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport. Arabidopsis SWEET8 is essential for pollen viability, and the rice homologues SWEET11 and SWEET14 are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter. Bacterial symbionts and fungal and bacterial pathogens induce the expression of different SWEET genes, indicating that the sugar efflux function of SWEET transporters is probably targeted by pathogens and symbionts for nutritional gain. The metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary cells.
一組以前不知道的糖運(yùn)輸?shù)鞍滓驯蛔R別出來——zui初是在植物中， 但由于同源蛋白明顯廣泛分布，所以它們也在動物中被識別出。
在植物中，這些SWEET受體相應(yīng)于那些人們長期尋找的、向花蜜、種子和花粉發(fā)育供應(yīng)葡萄糖的運(yùn)輸?shù)鞍?。這些運(yùn)輸?shù)鞍字械钠渲幸恍┍徊≡w利用來為復(fù)制提供糖。后生動物同源蛋白也調(diào)控葡萄糖運(yùn)輸，并且還可能涉及糖從小腸、肝臟、附睪和乳腺細(xì)胞中的流出。（生物谷）
英文摘要：
Nature doi:10.1038/nature09606
Sugar transporters for intercellular exchange and nutrition of pathogens
Li-Qing Chen, Bi-Huei Hou, Sylvie Lalonde, Hitomi Takanaga, Mara L. Hartung, Xiao-Qing Qu, Woei-Jiun Guo, Jung-Gun Kim, William Underwood, Bhavna Chaudhuri, Diane Chermak, Ginny Antony, Frank F. White, Shauna C. Somerville, Mary Beth Mudgett & Wolf B. Frommerwfrommer@carnegiescience.edu
Sugar efflux transporters are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. Despite broad biological importance, the identity of sugar efflux transporters has remained elusive. Using optical glucose sensors, we identified a new class of sugar transporters, named SWEETs, and show that at least six out of seventeen Arabidopsis, two out of over twenty rice and two out of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport. Arabidopsis SWEET8 is essential for pollen viability, and the rice homologues SWEET11 and SWEET14 are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter. Bacterial symbionts and fungal and bacterial pathogens induce the expression of different SWEET genes, indicating that the sugar efflux function of SWEET transporters is probably targeted by pathogens and symbionts for nutritional gain. The metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary cells.