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上海士鋒科技：樹突細(xì)胞在免疫過度反應(yīng)中的作用
最近更新時間：2013-7-7
提 供 商：上海士鋒生物科技有限公司資料大?。?/span>14KB
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究人員證實當(dāng)身體免疫反應(yīng)過于活躍且可能造成傷害時，樹突細(xì)胞也能夠在抑制這種免疫反應(yīng)中發(fā)揮著作用。事實上，它們能夠作為免疫系統(tǒng)的調(diào)節(jié)者發(fā)揮作用，有助于抑制免疫系統(tǒng)。
當(dāng)免疫系統(tǒng)對過敏原作出過度反應(yīng)時，過敏反應(yīng)就會產(chǎn)生。研究人員說，他們的發(fā)現(xiàn)讓人們對參與過敏反應(yīng)的免疫反應(yīng)類型產(chǎn)生新的認(rèn)識。
研究人員通過在小鼠體內(nèi)和實驗室測試中研究免疫反應(yīng)而證實了上述發(fā)現(xiàn)。他們說，它有助于解釋身體如何控制抵御感染的戰(zhàn)斗和如何尋求恢復(fù)穩(wěn)定，而且它可能讓人們能夠控制在過敏反應(yīng)中發(fā)現(xiàn)的炎癥。
Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo
Peter C. Cooka,1, Lucy H. Jonesa,1, Stephen J. Jenkinsa, Thomas A. Wynnb, Judith E. Allena, and Andrew S. MacDonald
Interleukin-4 is a cytokine widely known for its role in CD4+ T cell polarization and its ability to alternatively activate macrophage populations. In contrast, the impact of IL-4 on the activation and function of dendritic cells （DCs） is poorly understood. We report here that DCs respond to IL-4 both in vitro and in vivo by expression of multiple alternative activation markers with a different expression pattern to that of macrophages. We further demonstrate a central role for DC IL-4Rα expression in the optimal induction of IFNγ responses in vivo in both Th1 and Th2 settings, through a feedback loop in which IL-4 promotes DC secretion of IL-12. Finally, we reveal a central role for RELMα during T-cell priming, establishing that its expression by DCs is critical for optimal IL-10 and IL-13 promotion in vitro and in vivo. Together, these data highlight the significant impact that IL-4 and RELMα can have on DC activation and function in the context of either bacterial or helminth pathogens.