| CBP73377 | |
| I. Introduction | |
Cell Line Name： | FGFR3-TACC3 [K650N] /BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
FGFR3-TACC3 results from the fusion of FGFR3 and TACC3, demonstrating constitutive kinase activity, transforming activity in culture and ability to drive tumor growth in xenografts (PMID: 25294908, PMID: 22837387). FGFR3-TACC3 has been identified in lung adenocarcinoma and glioblastoma (PMID: 25294908, PMID: 22837387). | |
| III. Representative Data | |
1.WB of FGFR3-TACC3 [K650N] /BaF3
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2. Sanger of FGFR3-TACC3 [K650N] /BaF3
Figure 2. FGFR3-TACC3 [K650N] /BaF3 K650N
Figure 3. FGFR3-TACC3 [K650N] /BaF3 FGFR3-TACC3 | |
3. Anti-proliferation assay
Figure 4. CTG Proliferation Assay of BaF3 FGFR3-TACC3 K650N Cells (C3). | |
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