艾美捷滅瘟素S Blasticidin S英文說明書：

CATALOGUE NUMBER

PRO-553

SYNONYMS

Beta-2-microglobulin, B2M.

INTRODUCTION

Beta 2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of Beta 2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I.

Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces.

DESCRIPTION

Human Beta-2 Microglobulin produced in Human urine from patients with tubular proteinuria having a molecular mass of 12KDa.

SOURCE

Human urine from patients with tubular proteinuria.

PHYSICAL APPEARANCE

Sterile Filtered White lyophilized (freeze-dried) powder.

FORMULATION

Lyophilized from 0.02M NH4HCO3.

SOLUBILITY

It is recommended to reconstitute the lyophilized HuB2M in phosphate buffer pH > 7.0 containing 0.15M NaCl.

艾美捷滅瘟素S Blasticidin S中文說明書：

艾美捷滅瘟素S Blasticidin S 是一種肽基核苷抗生素。它首先是從S. griseochromogenes中分離出來的。五水合物形式的結(jié)構(gòu)是使用衍射儀數(shù)據(jù)確定的，與抗生素阿米西丁類似，親水基團(tuán)和疏水基團(tuán)位于分子的兩側(cè)。它是使用全合成創(chuàng)建的。

艾美捷滅瘟素S Blasticidin S（鹽酸鹽）用于研究選擇用殺稻瘟素抗性基因bsr轉(zhuǎn)染的哺乳動(dòng)物細(xì)胞。不供人類或獸醫(yī)使用。

艾美捷滅瘟素S Blasticidin S化學(xué)性質(zhì)：

正式名稱：4-[[(3S)-3-氨基-5- [(氨基亞氨基甲基)甲基氨基]-1-氧代戊基]氨基]-1- (4-氨基-2-氧代-1(2H)-嘧啶基)- 1,2,3,4-四脫氧-β-D-赤型-己-2-烯吡喃糖醛酸，單鹽酸鹽

CAS 編號：3513-03-9

分子式：C 17 H 26 N 8 O 5 • HCl

配方重量：458.9

純度：≥95%

公式：結(jié)晶固體

溶解度：H2O/HAc (50:50)：10mg/mL

起源：細(xì)菌/灰色鏈霉菌

貯存：-20°C

船運(yùn)：美國大陸的室溫；其他地方可能會(huì)有所不同

穩(wěn)定：≥ 4 年