MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。

PMSF

CAS No. : 329-98-6

MCE 國際站：PMSF

產(chǎn)品活性：PMSF是通常用于制備細胞裂解物的不可逆的絲氨酸/半胱氨酸蛋白酶抑制劑。

研究領(lǐng)域：Metabolic Enzyme/Protease

作用靶點：Cathepsin

In Vitro: PMSF (2 mM) inhibits carbachol-stimulated inositol phosphate accumulation in the presence of Li⁺ by only 15%-19%. PMSF inhibition of phosphoinositide turnover is due to one or more steps following phosphoinositide breakdown. PMSF inhibits the acylation of the inositol residue of GPI intermediates in bloodstream-form T. brucei. PMSF inhibits the formation of glycolipid C but does not inhibit fatty acid remodeling in vitro. PMSF inhibits GPI acylation and ethanolamine phosphate addition in procyclic trypanosomes but not in Hela cells.

In Vivo: PMSF (0.1 mL/10 g b.wt, i.p.) produces antinociception as indicated by the dose-responsive increase in % MPE in the tail-flick latency evaluation, but fails to produce a clear dose-responsive inhibition of locomotion. Mice receiving i.p. injections of PMSF exhibit cannabinoid effects that includes antinociception, hypothermia and immobility with ED₅₀ values of 86, 224 and 206 mg/kg, respectively. PMSF (30 mg/kg) pretreatment potentiates the effects of anandamide on tail-flick response (antinociception), spontaneous activity and mobility by 5-, 10- and 8-fold, respectively.

相關(guān)產(chǎn)品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Covalent Screening Library  |  Angiogenesis-Related Compound Library  |  Human Metabolite Library  |  Membrane Protein-targeted Compound Library  |  Ac-VLPE-FMK  |  Cathepsin X-IN-1  |  RO5461111  |  Balicatib  |  MK-0674  |  Cathepsin D and E FRET Substrate acetate  |  L-006235  |  Arg-Arg-AMC  |  CA-074 methyl ester  |  Ac-Leu-Val-Lys-Aldehyde  |  Papain  |  VBY-825  |  Cathepsin inhibitor 1  |  Z-Arg-Arg-4MβNA triacetate  |  Hepcidin-1 (mouse) (TFA)  |  L-873724  |  Cathepsin C-IN-4  |  Cathepsin C-IN-3  |  Odanacatib  |  N-CBZ-Phe-Arg-AMC  |  Cysteine Protease inhibitor  |  Z-FA-FMK  |  Relacatib  |  E-64  |  2-Cyanopyrimidine  |  Cathepsin C-IN-5  |  ALLM  |  Z-LVG-CHN2  |  SID 26681509 quarterhydrate  |  Gü1303

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry