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Beta III-tubulin is frequently overexpressed in human tumors and is associated with resistance to microtubule-targeting agents, tumor aggressiveness, and poor patient outcome [PMID: 34364992

IF: 9.7 Q1 B1]. In prostate cancer, βIII-tubulin expression is strongly associated with both TMPRSS2: ERG rearrangement, ERG expression and PTEN deletions, three key oncogenetic features of aggressive prostate cancer [PubMed: 24378408]. Also, colorectal cancer is more aggressive in young male patients in whom testosterone elevation and activation of TUBB3 are connected with poor outcome [PubMed: 23637935].