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CD184, also known as CXCR4 or Fusin, is a seven-transmembrane G protein-coupled receptor that plays a crucial role in various physiological processes. It is widely expressed on hematopoietic cells, including lymphoid and myeloid precursor cells, megakaryocytes, and endothelial cells. Its natural ligand is stromal cell-derived factor-1 （SDF-1）, a C-X-C chemokine that induces chemotaxis and enhances intracellular signaling through calcium ion influx and MAPK activation.