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CD14 is a glycosylphosphatidylinositol （GPI）-anchored membrane glycoprotein primarily expressed on monocytes, macrophages, and some granulocytes. It functions as a pattern recognition receptor （PRR） and plays a crucial role in the innate immune response by recognizing bacterial lipopolysaccharides （LPS）, pathogen-associated molecular patterns （PAMPs）, and damage-associated molecular patterns （DAMPs）. CD14 exists in two forms: membrane-bound CD14 （mCD14） and soluble CD14 （sCD14）, which can be secreted by activated cells. It acts as a co-receptor for Toll-like receptor 4 （TLR4） and enhances the immune response to LPS by facilitating its delivery to the TLR4-MD2 complex. Additionally, CD14 is involved in TLR4-independent signaling pathways and contributes to tissue homeostasis by promoting the clearance of apoptotic cells.