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S100A13 is a 11 kDa member of the S100 （soluble in 100% saturated ammonium sulfate） family of vertebrate EF-Hand CA ion binding protein. S100A13 is widely expressed in various types of tissue, and high protein expression is detected in thyroid filter cells, testicular Leydig cells, and brain -specific cells. S100A13 can regulate the secretion of FGF1 and IL1α, and has potential to become a symbol for the production of tumors and endometrial vascular. CK19 and S100A13 in cPTC are significantly increased, indicating that S100A13 may be regarded as a new candidate PTC biomarker.