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ERG is an ETS family transcription factor （TF） frequently involved in human cancers, including leukemia [PMID: 21664289], prostate cancer [PMID: 16254181] and Ewing’s sarcoma [PMID: 8223458, PMID: 10561219]. It functions as an oncogene through chromosomal translocations or overexpression. In human leukemia, ERG was initially thought to play a role in leukemogenesis based on the t（16;21） translocation in acute myeloid leukemia （AML）, leading to formation of the FUS （TLS）-ERG fusion [PMID: 8234289]. In some cases of AML with this translocation, the leukemia exhibits features of acute megakaryoblastic leukemia [PMID: 12091356].