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Mesothelin （MSLN） is a glycophosphatidylinositol （GPI）-linked cell surface protein normally expressed in mesothelial cells that line the pleura, peritoneum, and pericardium. The MSLN gene encodes a precursor protein of 71 kDa that is processed to a 31 kDa shed protein called MPF （megakaryocyte potentiating factor） and a 40 kDa membrane bound protein, mesothelin. Mesothelin is reported to be highly expressed in several types of malignant tumors, such as malignant mesothelioma, ovarian cancer, pancreatic adenocarcinoma, and lung adenocarcinoma.