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Interleukin-1 beta （IL-1β） is a proinflammatory cytokine that is mainly produced by monocytes and activated macrophages as a proprotein. Inflammatory responses are mediated by IL-1β in T cells, natural killer cells （NK cells） and B cells. It induces the production of pro-inflammatory cytokines （IL-2, IL-3, IL-6） as well as interferons. Furthermore, IL-1β modulates the secretion of cytokines by various subsets of human DCs.