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The type-I interferons （IFN） are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. The IFN-β proteins are produced in large quantities by fibroblasts. They have antiviral activity that is involved mainly in innate immune response. Two types of IFN-β have been described, IFN-β1 （IFNB1） and IFN-β3 （IFNB3）. In mice, IFN-β inhibits immune cell production of growth factors, thereby slowing tumor growth, and inhibits other cells from producing vessel-producing growth factors, thereby blocking tumor angiogenesis and hindering the tumour from connecting into the blood vessel system.