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Tumor necrosis factor alpha （TNFa） is a multifunctional proinflammatory cytokine synthesized mainly by nucleated blood?
cells as a 233 aa type II transmembrane protein which is cleaved by ADAM17 between aa 76-77 to form a soluble?
homotrimeric complex. TNFa plays a role in lipid metabolism, coagulation, and endothelial function and has been?
associated with cancer, infection and inflammation （including inflammatory bowel disease）, ischemia/reperfusion injury?
and heart failure, and insulin resistance.