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CD20 is a 33-37 kDa non-glycosylated protein present on the surface of normal and malignant B lymphocytes and is a member of the MS4A （membrane-spanning 4-domain family A） protein family. The CD20 protein comprises four hydrophobic transmembrane domains, one intracellular domain, and two extracellular domains （a large loop and a small loop）, with both the N- and C-termini located within the cytosol. CD20 is associated with several key molecules, including the major histocompatibility complex class II （MHCII）, CD40 molecule, B-cell receptor （BCR）, and the C-terminal src kinase-binding protein （CBP）. CBP interacts with Src kinases such as LYN, FYN, and LCK.
A deficiency in CD20 has been shown to result in a reduced number of circulating memory B cells, decreased isotype switching of immunoglobulins （Ig）, and lower IgG antibody levels. It is also linked to various pathophysiological diseases and disorders.
CD20 plays a crucial role in multiple physiological processes and is thus a promising therapeutic target. The CD20 protein product has the potential to enhance drug discovery efforts in related fields.