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非布司他適應(yīng)癥及作用機(jī)理：非布司他主要成份為非布佐司他，其化學(xué)名為2-[(3-氰基-4-異丁氧基)苯基]-4-甲基-5-噻唑羧酸。為黃嘌呤氧化酶（XO）抑制劑，適用于具有痛風(fēng)癥狀的高尿酸血癥的長期治療。非布佐司他是黃嘌呤氧化酶抑制劑，通過減少血清尿酸達(dá)到療效。本品在治療濃度下不會抑制嘌呤和嘧啶的合成及代謝過程中的其他酶。
深圳遠(yuǎn)揚(yáng)化學(xué)技術(shù)有限公司提供的非布司他雜質(zhì)純度高，來源正規(guī)，*非布司他新藥申報(bào)的要求，隨貨提供COA證書，氫譜，質(zhì)譜及HPLC，。（請點(diǎn)擊本頁標(biāo)題下方“進(jìn)入該公司展臺” 查看我司信息）。
| Febuxostat | 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 1 | ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 2 | ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 3 | ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 4 | 2-(3-carbamoyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 5 | ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 6 | (E)-ethyl 2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 7 | (E)-2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 8 | 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 9 | 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 10 | 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid 1-oxide |
| Febuxostat Impurity 11 | 2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 12 | 4-isobutoxybenzene-1,3-bis(carbothioamide) |
| Febuxostat Impurity 13 | dimethyl 2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylate) |
| Febuxostat Impurity 14 | 2-isobutoxy-5-(4-methylthiazol-2-yl)benzonitrile |
| Febuxostat Impurity 15 | 2-(4-butoxy-3-cyanophenyl)thiazole-5-carboxylic acid |
| Febuxostat Impurity 16 | 2-(4-(sec-butoxy)-3-cyanophenyl)thiazole-5-carboxylic acid |
| Febuxostat Impurity 17 | 2-(3-cyano-4-propoxyphenyl)thiazole-5-carboxylic acid |
| Febuxostat Impurity 18 | ethyl 2-(4-hydroxy-3-vinylphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 19 | ethyl 2-(2-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 20 | 2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylic acid) |
| Febuxostat Impurity 21 | diethyl 2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylate) |
| Febuxostat Impurity 22 | ethyl 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 23 | 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 24 | 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 25 | 2-(3-carboxy-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 26 | 2-(3-carbamoyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 27 | 2-(4-butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 28 | 2-(4-(sec-butoxy)-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 29 | 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 30 | 2-(3-cyano-4-ethoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 31 | (E)-ethyl 2-(4-hydroxy-3-((hydroxyimino)methyl)phenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 32 | ethyl 2-(3-formyl-2-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 33 | 2-(3-cyano-4-isopropoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 34 | isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 35 | methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 36 | 2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 37 | ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 38 | 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
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