IL-5

白細(xì)胞介素 5 (IL-5, IL5) 由活化的 CD4+ TH2 型細(xì)胞、NK 細(xì)胞、肥大細(xì)胞和 B 細(xì)胞產(chǎn)生。它專門控制嗜酸性粒細(xì)胞的產(chǎn)生、激活和定位。

艾美捷抗人IL-5單抗5A10：

這種單克隆抗體能夠在 ELISA 和 ELISpot 等免疫分析中靈敏且特異地檢測(cè)人 IL-5。

推薦 5A10 作為 ELISA 和 ELISpot 中的檢測(cè)抗體與捕獲抗體 TRFK5 結(jié)合使用。

艾美捷抗人IL-5單抗5A10非人類靈長(zhǎng)類動(dòng)物交叉反應(yīng)：

與 NHP 反應(yīng)的系統(tǒng)要么基于交叉反應(yīng)的人類試劑盒，要么基于專門開發(fā)的猴子試劑盒 (NHP)。

交叉反應(yīng)性驗(yàn)證測(cè)試已由 Mabtech 和/或其他人在 ELISpot 和/或 ELISA 中進(jìn)行。交叉反應(yīng)證據(jù)較少的測(cè)定被定義為適應(yīng)癥。

艾美捷抗人IL-5單抗5A10文獻(xiàn)參考：

Minang, J. T., et al. (2008). ELISpot displays a better detection over ELISA of T helper (Th) 2-type cytokine-production by ex vivo-stimulated antigen-specific T cells from human peripheral blood. Immunological investigations.

Mola, P. W., et al. (1999). Cytokine control of the granulomatous response in Schistosoma mansoni-infected baboons: role of exposure and treatment. Infection and immunity.

Schulten, V., et al. (2013). Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals. Proceedings of the National Academy of Sciences of the United States of America.

Seumois, G., et al. (2016). Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma. Journal of immunology.

Shastri, M. D., et al. (2015). Opposing Effects of Low Molecular Weight Heparins on the Release of Inflammatory Cytokines from Peripheral Blood Mononuclear Cells of Asthmatics. PLoS ONE.