作者：Shashwat S. Banerjee,a   Kiran J. Todkar,a   Ganesh V. Khutale,a   Govind P. Chate,b   Ankush V. Biradar,c   Manoj B. Gawande,d   Radek Zboril,d and  Jayant J. Khandareb

a Actorius Innovations and Research, 100 NCL Innovation Park, Pune-411008, India 

b Maharashtra Institute of Pharmacy, Maharashtra Institute of Technology Campus, Kothrud, Pune-411038, India 

c Catalysis Division, CSIR-National Chemical Laboratory, Pune-411008, India 

d Regional Centre of Advanced Technologies and Materials, Faculty of Science, Department of Physical Chemistry, Palacky University, Šlechti? 11, Olomouc, Czech Republic

 

摘要：We report calcium phosphate (CaP) nanocapsule crowned multiwalled carbon nanotubes (CNT–GSH–G4–CaP) as a novel platform for intracellular delivery of an anticancer drug. As a proof-of-concept, CNT–GSH–G4–CaP demonstrates release of anticancer drug doxorubicin hydrochloride (DOX) within intracellular lysosomes from the interior cavity of CNT upon pH triggered CaP dissolution. Importantly, we found that the CNT with a CaP nanolid can efficiently prevent untimely drug release at physiological pH but promotes DOX release at increased acidic milieu as observed in subcellular compartments such as lysosomes (5.0). This “zero premature release” characteristic is of clinical significance in delivering cytotoxic drugs, by reducing systemic toxicity and thus beneficial for the effective anticancer treatment. We envision that this pH triggered CaP crowned CNT nanosystem would lead to a new generation of self-regulated platforms for intracellular delivery of a variety of anticancer drugs.