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英文名稱  Anti-C1orf124 
中文名稱   
別    名  C1orf124; CA124_HUMAN; Chromosome 1 open reading frame 124; DDDL1880; dJ876B10.3; PRO4323; RP5-876B10.3; Zinc finger RAD18 domain-containing protein C1orf124.  
濃    度  1mg/1ml 
規(guī) 格  0.2ml/200μg   
抗體來源  Rabbit  
克隆類型  polyclonal 
交叉反應(yīng)  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit  
產(chǎn)品類型  一抗    
研究領(lǐng)域  腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué)  
蛋白分子量  predicted molecular weight: 55kDa 
性    狀  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human C1orf124 
亞    型  IgG 
純化方法  affinity purified by Protein A 
儲 存 液  Preservative: 15mM Soium zde, Constituents: 1% BSA, 0.01M PBS, pH 7.4 
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產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 
（石蠟切片需做抗原修復(fù)） 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
產(chǎn)品介紹 Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf124 gene product has been provisionally designated C1orf124 pending further characterization.
Function : Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. 
Subunit : Interacts with PCNA (when ubiquitinated). Interacts with RAD18. Interacts (via its SHP-box) with VCP/p97. Interacts with KCTD13 and POLD3. 
Subcellular Location : Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled relication forks at sites of replication stress.
Similarity : Belongs to the Spartan family. 
Contains 1 SprT-like domain. 
Contains 1 UBZ-type zinc finger. 
Database links : UniProtKB/Swiss-Prot: Q9H040.2
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