S0B0681 Mouse Anti-Human CD11c Antibody
- 公司名稱 杭州斯達特生物科技有限公司
- 品牌 Starter/斯達特
- 型號 S0B0681
- 產(chǎn)地 浙江 杭州
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2025/8/6 16:51:18
- 訪問次數(shù) 37
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CD11c is a type I transmembrane glycoprotein of approximately 150 kDa, also known as integrin alpha X (Itgax). It is part of the complement receptor 4 (CR4) complex and, along with CR3 (also known as Mac-1 or CD11b/CD18), belongs to the β2-integrin family of adhesion molecules. CD11c is primarily expressed on dendritic cells (DCs), NK cells, a subset of intestinal intraepithelial lymphocytes (IELs), and some activated T cells. It is involved in cell adhesion, migration, and phagocytic functions, mediating the phagocytic process of DCs through its association with β2-integrin. Under conditions of early development and in certain neurodegenerative diseases such as Alzheimer's disease (AD), a subset of microglia in the central nervous system also expresses CD11c. CD11c+ microglia express genes such as Spp1, which encodes osteopontin (OPN), a cytokine-like phosphorylated protein involved in pathogenic and protective immune responses in peripheral lymphoid tissues. Additionally, CD11c serves as a marker for macrophages, whose expression aids researchers in identifying and characterizing these cells, thus contributing to a deeper understanding of their roles in immune and inflammatory processes.
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