CD206, also known as the mannose receptor, is a highly glycosylated type I transmembrane protein predominantly found on the surface of macrophages and dendritic cells. It plays a crucial role in the immune system by mediating the internalization of soluble and particulate carbohydrate structures, thus participating in innate immunity. CD206 serves as a marker for M2-type macrophages, which are characterized by their anti-inflammatory properties and are involved in processes such as wound healing and immune tolerance. These M2 macrophages are often associated with tumor progression, as they can promote tumor growth and metastasis by suppressing anti-tumor immunity. Additionally, CD206 acts as a pattern recognition receptor for various pathogens, including bacteria, fungi, and viruses, by recognizing their mannan-coated cell walls or envelopes. This receptor is also implicated in the clearance of apoptotic cells and the regulation of immune responses, making it an important target for studying immune modulation and disease pathogenesis.