CD62L, also known as L-selectin, is a type-I transmembrane glycoprotein and a member of the selectin family of adhesion molecules, primarily expressed on the surface of leukocytes such as T cells, B cells, and natural killer cells. It plays a crucial role in leukocyte homing and immune cell localization, facilitating the initial adhesion and rolling of white blood cells to endothelial cells during inflammation. CD62L is essential for the migration of na?ve and central memory T cells into secondary lymphoid organs like lymph nodes, where it helps initiate and regulate immune responses. Additionally, CD62L serves as a phenotypic marker for central memory T cells, which have higher expression levels of this molecule and can rapidly respond to antigen re-exposure. In cancer immunotherapy, modulating CD62L expression can enhance T cell infiltration into the tumor microenvironment, improving treatment efficacy.